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  • DBS Autosampler
  • PicoOnlineSPE System
  • YL6100 PC 1
  • Ecosec Offen72
  • Osmomat3000
  • Interchim Puriflash

instrumenter

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Elektrokemiske reaktorer for MS og synthese

Using Electrochemistry (EC) as a reaction technique before the MS allows the analyst to mimic natures’ REDOX reactions in almost any analytical field. Many chemical and catalytic reactions (wet chemistry, Fenton, etc.) can be mimicked in a controlled manner in the electrochemical cell simply by applying a voltage potential.

A large number of biochemical reactions such as enzymatic, micorbial, aquatic, photolytic, etc, can be simulated without biological interferences (e.g. cell matrix, plasma, urine, soil, etc.) and the generated REDOX products can be easily detected by MS, making EC/MS a real biomimetic tool with substantial cost and time savings compared to in-vivo or in–vitro techniques. 

ROXY Systems

Mimicking nature's redox reactions

  • Fast synthesis of metabolites (µ-preparative)
  • Rapid risk assessments of drug-protein binding
  • Signal enhancement in MS
  • Electrochemical cleavage of proteins/peptides
  • Reduction of disulfide bonds
  • Oxidative stress/damage of proteins, DNA, lipids, etc.

The on-line coupling of Electrochemistry (EC) with LC/MS has shown great potential for the investigation of drug metabolism. It offers fast electrochemical synthesis of drug metabolites for reliable quantification by mass spectrometry (MS) to be operated as a high throughput screening system. The ROXY EC system and the ROXY EC/LC system provide all the tools for EC/MS research. For further explanation see the video recording of the ASMS presentation of prof Uwe Karst (2010) and the tutorials on our website, such as a computer animation on YouTube made by University of Twente.

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ROXY EC/LC for MS

Dedicated Electrochemistry/UHPLC System for EC/LC/MS

With the introduction of the ROXY™ EC/LC System, Antec brings Electrochemistry (EC) to the fingertips of every mass spectrometrist. It makes on-line EC/LC/MS for automated screening of numerous samples available for the first time.

ROXY EC for MS

Dedicated Electrochemistry system for EC/MS

The ROXY™ EC is the ideal introduction system for Electrospray Ionization (ESI)-MS for single compound conversion. For known compounds (e.g., drug candidates, pollutants, pesticides, etc) a quick profiling and/or reconfirmation of potential metabolites is often sufficient for decision making.

ROXY Potentiostat

ROXY™ Potentiostat controls REDOX reactions

The ROXY Potentiostat is recognised as one of the most powerful instruments for controlled REDOX reactions up-front Mass Spectrometric detection. It fits with any MS and can be controlled easily via a contact closure.

ROXY qualification procedures

Antec developed procedures and kits for Installation Qualification (IQ), Performance Qualification (PQ) and Operational Qualification (OQ) for ALEXYS and ROXY systems and system components. An IQ consists of a list of requirements prior to installation, and a checklist covering the delivery and instructions for use.

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