DryLab Software for HPLC Method Development
DryLab is the revolutionary HPLC method development and optimization software that predicts chromatograms under a much wider range of experimental conditions than would ever be possible in the laboratory. With DryLab you can quickly and easily determine exactly how your separation behaves as you simultaneously vary multiple method parameters, such as pH, temperature, buffer concentration, and many more. Anybody developing HPLC methods who wishes to optimize complex samples and to economize resources spent developing and running methods will benefit from the many advantages offered by
How does DryLab work?
Define Method Goals and Run Input Experiments
The beauty of DryLab is that with data generated from only 2-12 input experiments, DryLab predicts resolution and retention times for millions of unique, virtual chromatograms. The first step to using DryLab is to define your analytical target profile (ATP) and let DryLab help you choose your systematic approach and initial method conditions. Then simply run your input experiments and upload them as *.cdf files, which is the universal format for chromatographic data systems.ting the impact of small fluctuations on up to six critical separation parameters. You can determine which parameters exert the greatest influence on the method and therefore must be strictly controlled to achieve 100% success in routine applications.
Easily and Quickly Match Peaks
DryLab offers a number of user friendly features to help you manage your input runs, streamline your peak tracking, and control for errors. Once you’ve generated matched peak table, you’re ready to build your model!
Build Model & Select Working Point
Based on your Design of Experiments (DoE), DryLab creates multi-dimensional resolution models that depict the set of conditions under which you’ll achieve baseline separation or higher. You can view the predicted chromatogram for any point within your model, and with only one mouse click, select the working point with the highest critical resolution. DryLab predicts peak width and retention times with >99% accuracy!
Evaluate Additional Parameters
You can further predict how changes in many additional method parameters affect your separation, such as flow rate, column dimensions, instrument parameters, and eluent in gradient and isocratic conditions. This provides maximum flexibility for method optimization and method transfer.
Test Robustness Thresholds
Once you’ve selected your working point, you can test the separation’s tolerance limits by evaluating the impact of small fluctuations on up to six critical separation parameters. You can determine which parameters exert the greatest influence on the method and therefore must be strictly controlled to achieve 100% success in routine applications.
Create GMP Method Documentation
Your last step is to create a comprehensive Knowledge Management report, which pulls all your method data directly from DryLab, and provides you with a platform to justify and comment on your method criteria and choices. This report is GMP compliant and the perfect tool for better knowledge sharing.