The Calypso® automated composition-gradient accessory and software are used in conjunction with a MALS detector (CG-MALS) to characterize biomolecular interactions, label-free and immobilization-free. CG-MALS determines equilibrium dissociation constants self- and hetero-association as well as more complex interactions.

Also useful for automation of Zimm plots, dn/dc analysis, reaction kinetics and polymer interaction analyses.

Label-free, immobilization-free characterization of protein-protein and other macromolecular interactions with composition-gradient multi-angle light scattering.


The Calypso® II, in conjunction with a DAWN® or miniDAWN® MALS detector, measures binding affinities and absolute, molecular stoichiometries of complex biomolecular interactions.

Weight-Average Molar Mass

In addition to equilibrium association constants Kd and absolute stoichiometry of reversible self- and hetero-associations, it can also help determine reaction or aggregation rates, non-specific interaction parameters (virial coefficients) and even automate measurements of weight-average molar mass and dn/dc for polymers.

CALYPSO Software

Included with each Calypso is a copy of CALYPSO software, the most versatile software package available for analysis of biomolecular interactions in solution by light scattering.

For more details and price, please contact MD Scientific at or 7027 8565.

MD Scientific is an authorized distributor for Wyatt Technologi in Denmark, Norway og Sweden.